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Functional CAR-T Cells Convergence Team

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Single-Cell Functional Multi-omics to Characterize and Monitor CAR-T Therapy

Team Leader

  • Rong Fan, PhD

    Team Leader
    Associate Professor of Biomedical Engineering at Yale University
    + Full Bio

About This Team’s Research

Immunotoxicity and autoimmune-like response is a significant problem hindering widespread use of cancer immunotherapies. A major player in the immune response are cytokines, which are substances secreted by some immune cells to effect other cells in response to a signal, e.g., recognition of a foreign body. To understand this response, the full spectrum of cytokine functions in a pre-infusion setting will be assessed and matched with patient responses to treatment with the chimeric antigen receptor (CAR) T therapy. Afterward, the function of the infused CAR T cells will be assessed to determine the mechanisms of efficacy and/or immune toxicity. The team also proposes identifying molecular characteristics underlying therapeutic efficacy and toxicity of CAR T therapy, and biomarker discovery by using computational models and machine learning that look at the data. If successful, this will create a ‘tool’ that clinicians can use to mitigate patient risk associated with CAR T therapies while improving the chances of therapeutic success.

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