SU2C Scientific Research Teams
E. John Wherry, PhDScientific Research Team:
E. John Wherry, PhD
Dr. E. John Wherry is the Director of the Institute for Immunology and Professor of Microbiology at the University of Pennsylvania. Dr. Wherry’s expertise focuses on T cell exhaustion in chronic infections and cancer and the mechanisms “checkpoint” pathways such as PD-1 in preclinical models and in human trials. Dr. Wherry’s work has defined the molecular mechanisms of T cell exhaustion, including defining the role of inhibitory receptor biology, transcriptional control and regulation of T cell differentiation. This work has defined key principles about inhibitory receptor blockade and co-blockade to reverse T cell exhaustion. Dr. Wherry’s work has also defined central transcriptional and epigenetic pathways in the biology of exhausted T cells. Newer work is examining the links between DNA repair, genome maintenance and overstimulation of T cells as factors influencing the outcome of cancer immunotherapy. Major efforts continue in transcriptional profiling, genomics and computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings.