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SU2C Scientific Research Teams

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E. John Wherry, PhD

Scientific Research Team:
E. John Wherry, PhD

E. John Wherry, PhD

Dr. E. John Wherry is the Director of the Institute for Immunology and Professor of Microbiology at the University of Pennsylvania. Dr. Wherry’s expertise focuses on T cell exhaustion in chronic infections and cancer and the mechanisms “checkpoint” pathways such as PD-1 in preclinical models and in human trials. Dr. Wherry’s work has defined the molecular mechanisms of T cell exhaustion, including defining the role of inhibitory receptor biology, transcriptional control and regulation of T cell differentiation. This work has defined key principles about inhibitory receptor blockade and co-blockade to reverse T cell exhaustion. Dr. Wherry’s work has also defined central transcriptional and epigenetic pathways in the biology of exhausted T cells. Newer work is examining the links between DNA repair, genome maintenance and overstimulation of T cells as factors influencing the outcome of cancer immunotherapy.  Major efforts continue in transcriptional profiling, genomics and computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings.